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Proceedings Paper

Laser speckle contrast imaging of cerebral blood flow of newborn mice at optical clearing
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Paper Abstract

In this work, we consider the use of optical clearing agents to improve imaging quality of the cerebral blood flow of newborn mice. Aqueous 60%-glycerol solution, aqueous 70%-OmnipaqueTM(300) solution and OmnipaqueTM (300) solution in water/DMSO(25%/5%) were selected as the optical clearing agents. Laser speckle contrast imaging (LSCI) was used for imaging of cerebral blood flow in newborn mice brain during topical optical clearing of tissuesin the area of the fontanelle. These results demonstrate the effectiveness of glycerol and Omnipaque solutions as optical clearing agents for investigation of cerebral blood flow in newborn mice without scalp removing and skull thinning.

Paper Details

Date Published: 24 March 2017
PDF: 7 pages
Proc. SPIE 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII, 1033610 (24 March 2017); doi: 10.1117/12.2268358
Show Author Affiliations
Polina A. Timoshina, Saratov National Research State Univ. (Russian Federation)
Ekaterina M. Zinchenko, Saratov National Research State Univ. (Russian Federation)
Daria K. Tuchina, Saratov National Research State Univ. (Russian Federation)
Madina M. Sagatova, Saratov National Research State Univ. (Russian Federation)
Oxana V. Semyachkina-Glushkovskaya, Saratov National Research State Univ. (Russian Federation)
Valery V. Tuchin, Saratov National Research State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10336:
Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII
Valery V. Tuchin; Elina A. Genina; Dmitry E. Postnov; Vladimir L. Derbov, Editor(s)

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