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Proceedings Paper

Efficiency of use endobronchial laser doppler-flowmetry in patients with chronic leukemia
Author(s): E. A. Vanina; V. V. Voitsekhovskiy; Y. S. Landyshev; S. I. Tkacheva
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Paper Abstract

In this work indicatorsendobronchial microcirculation were investigated in patients with chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), multiple myeloma (MM), polycythemia vera (PV), idiopathic myelofibrosis (IMF). A diagnostic bronchoscopy was performed using fibreoptic «Olympus» (Japan).Endobronchial laser Doppler flowmetry was carried out on the laser analyzer capillary blood LAK-02 (Russia). Laser Doppler flowmetry indicators such as parameter of microcirculation, the oscillation amplitude in the endothelial, neurogenic, myogenic, cardiac and respiratory ranges were calculated by continuous the Wavelet transforms. Reduced cardiac and respiratory amplitudes in CML and CLL are primarily due to the development leukostasis. If PV is the case, this is due to sludge syndrome. And when MM occurs, it is caused by protein stasis in the vessels of the bronchial tubes. Increased endothelial oscillation amplitudes in the range in CML, PV, IMF and their reduction in MM indicate the presence of endothelial dysfunction in these patients. Increasing the amplitude of oscillations in the range of neurogenic indicates the development of arteriolar vasodilation as a compensatory response to the violation of blood flow. Increasing the amplitude of oscillations of myogenic tone indicating decrease precapillaries as a compensatory reaction to improve blood flow. It is concluded that endobronchial laser Doppler flowmetry is an important method allowing diagnosing the pathology of the microvasculature of the bronchi in chronic leukemia.

Paper Details

Date Published: 14 December 2016
PDF: 8 pages
Proc. SPIE 10176, Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics, 101760G (14 December 2016); doi: 10.1117/12.2268311
Show Author Affiliations
E. A. Vanina, Amur State Medical Academy (Russian Federation)
V. V. Voitsekhovskiy, Amur State Medical Academy (Russian Federation)
Y. S. Landyshev, Amur State Medical Academy (Russian Federation)
S. I. Tkacheva, Amur Regional Hospital (Russian Federation)


Published in SPIE Proceedings Vol. 10176:
Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics
Yuri N. Kulchin; Roman V. Romashko; Alexander V. Syuy, Editor(s)

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