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Proceedings Paper

The assesment of effectiveness of plasmonic resonance photothermal therapy in tumor-bearing rats after multiple intravenous administration of gold nanorods
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Paper Abstract

To assess the effectiveness of plasmonic photothermal therapy (PPT) multiple intravenous strategy of gold nanorods (GNRs) administration was used before laser exposure. The model of alveolar liver cancer PC-1 was used in male outbred albino rats, which were intravenously administrated by single and multiple injections of GNRs and then were treated by PPT. The gold dosage was 400 μg (single injection group), 800 μg (double injection group), 1200 μg (triple injection group), and absorption maximum of gold nanorods suspension was at the wavelength of 808 nm. 24 hours after last injection the tumors were irradiated by the 808-nm diode laser during 15 min at power density 2.3 W/cm2. Temperature control of the tumor heating was provided by IR imager. 24 hours after the PPT the half of animals from each group was withdrawn from the experiments and the sampling tumor tissue for morphological study was performed. In survived animals the growth of tumors was evaluated during 21 days after the PPT. The antitumor effects of PPT after triple intravenous injection were comparable with those obtained at direct intratumoral administration of similar total dose of GNRs. The effectiveness of PPT depended on gold accumulation in tumor, probably, due to sufficient vascularization of tumor tissue.

Paper Details

Date Published: 24 March 2017
PDF: 7 pages
Proc. SPIE 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII, 103360Q (24 March 2017); doi: 10.1117/12.2268293
Show Author Affiliations
Alla B. Bucharskaya, Saratov State Medical Univ. (Russian Federation)
Galina N. Maslyakova, Saratov State Medical Univ. (Russian Federation)
Nikita A. Navolokin, Saratov State Medical Univ. (Russian Federation)
Georgy S. Terentyuk, Saratov State Medical Univ. (Russian Federation)
National Research Saratov State Univ. (Russian Federation)
Boris N. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganics (Russian Federation)
Nikolai G. Khlebtsov, Saratov National Research State Univ. (Russian Federation)
Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Alexey N. Bashkatov, Saratov National Research State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
Elina A. Genina, Saratov National Research State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
V. V. Tuchin, Saratov National Research State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10336:
Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII
Valery V. Tuchin; Elina A. Genina; Dmitry E. Postnov; Vladimir L. Derbov, Editor(s)

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