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Proceedings Paper

ATP concentration as possible marker of liver damage at leukaemia treatment: confocal microscopy-based experimental study and numerical simulations
Author(s): V. Malashchenko; A. Zyubin; S. Babak; A. Lavrova
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Paper Abstract

We consider the method of confocal microscopy as a convenient instrument for determination of chemical compounds in biological tissues and cells. In particular, we study the dynamics of adenosine triphosphate (ATP) concentration that could be used as a bio-marker of energy metabolism pathologies at the treatment of acute lymphoblastic leukaemia (ALL). On the basis of data obtained by the confocal microscopy, the values of ATP concentration have been calculated for each case. Possible correlations with other characteristics of pathology processes obtained from plasma of leukemia patients show that ATP value could be a prognostic factor of the treatment success. The role of ATP in the drug metabolism switching is also discussed within the context of kinetic modelling of metabolism processes leading to the production of 6-Thioguanosine monophosphate, which is a principal acting agent in chemotherapy.

Paper Details

Date Published: 14 April 2017
PDF: 6 pages
Proc. SPIE 10337, Saratov Fall Meeting 2016: Laser Physics and Photonics XVII; and Computational Biophysics and Analysis of Biomedical Data III, 103371B (14 April 2017); doi: 10.1117/12.2267951
Show Author Affiliations
V. Malashchenko, Research Institute of Phthisiopulmonology (Russian Federation)
A. Zyubin, Research Institute of Phthisiopulmonology (Russian Federation)
S. Babak, Immanuel Kant Baltic Federal Univ. (Russian Federation)
A. Lavrova, Research Institute of Phthisiopulmonology (Russian Federation)
Immanuel Kant Baltic Federal Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10337:
Saratov Fall Meeting 2016: Laser Physics and Photonics XVII; and Computational Biophysics and Analysis of Biomedical Data III
Vladimir L. Derbov; Vladimir L. Derbov; Dmitry Engelevich Postnov; Dmitry Engelevich Postnov, Editor(s)

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