Share Email Print
cover

Proceedings Paper

Stiffness of RBC optical confinement affected by optical clearing
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In vivo optical trapping is a novel applied direction of an optical manipulation, which enables one to noninvasive measurement of mechanical properties of cells and tissues in living animals directly. But an application area of this direction is limited because strong scattering of many biological tissues. An optical clearing enables one to decrease the scattering and therefore increase a depth of light penetration, decrease a distortion of light beam, improve a resolution in imaging applications. Now novel methods had appeared for a measurement an optical clearing degree at a cellular level. But these methods aren’t applicable in vivo. In this paper we present novel measurement method of estimate of the optical clearing, which are based on a measurement of optical trap stiffness. Our method may be applicable in vivo.

Paper Details

Date Published: 24 March 2017
PDF: 7 pages
Proc. SPIE 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII, 103360U (24 March 2017); doi: 10.1117/12.2267942
Show Author Affiliations
Oleg V. Grishin, National Research Saratov State Univ. (Russian Federation)
Ivan V. Fedosov, National Research Saratov State Univ. (Russian Federation)
Valery V. Tuchin, National Research Saratov State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10336:
Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII
Valery V. Tuchin; Elina A. Genina; Dmitry E. Postnov; Vladimir L. Derbov, Editor(s)

© SPIE. Terms of Use
Back to Top