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Development of an optical biosensor for the detection of antibiotics in the environment
Author(s): Patricia Weber; Julian Vogler; Günter Gauglitz
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Paper Abstract

Pharmacologically active substances like antibiotics, hormones, x-ray contrast media, antirheumatic drugs or beta blockers are increasingly accumulating in the environment. These pharmacologically active substances can be found in surface waters as well as in food products. In the case of surface waters, the contamination with pharmacologically active substances is primary caused by incorrect disposal of drugs and by human and animal feaces. This is due to the fact that, drugs are only removed incompletely during the wastewater treatment. Furthermore, food of animal origin like milk, cheese, eggs or meat are potentially frequently concerned. The use of animal drugs in animal husbandry and food industry is permitted legal and a standard practice. However, it is possible that after drug application to animals drug residues or decomposition products remain in the animal carcasses. In this work we will present the first steps of the development of an optical biosensor sensitive for the antibiotic penicillin G. This biosensor is principle of the label-free and time resolved method Reflectometric Interference Spectroscopy (RIfS). The method uses interference of white light at thin layers to observe molecular interactions. The required surface modifications for the sensor were developed and optimized. Moreover, common commercial antibodies were chosen and concentration dependent measurements in buffer were performed.

Paper Details

Date Published: 16 May 2017
PDF: 9 pages
Proc. SPIE 10231, Optical Sensors 2017, 102312L (16 May 2017); doi: 10.1117/12.2267467
Show Author Affiliations
Patricia Weber, Eberhard Karls Univ. Tübingen (Germany)
Julian Vogler, Eberhard Karls Univ. Tübingen (Germany)
Günter Gauglitz, Eberhard Karls Univ. Tübingen (Germany)


Published in SPIE Proceedings Vol. 10231:
Optical Sensors 2017
Francesco Baldini; Jiri Homola; Robert A. Lieberman, Editor(s)

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