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Proceedings Paper

Evaluation of feature selection algorithms for classification in temporal lobe epilepsy based on MR images
Author(s): Chunren Lai; Shengwen Guo; Lina Cheng; Wensheng Wang; Kai Wu
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Paper Abstract

It's very important to differentiate the temporal lobe epilepsy (TLE) patients from healthy people and localize the abnormal brain regions of the TLE patients. The cortical features and changes can reveal the unique anatomical patterns of brain regions from the structural MR images. In this study, structural MR images from 28 normal controls (NC), 18 left TLE (LTLE), and 21 right TLE (RTLE) were acquired, and four types of cortical feature, namely cortical thickness (CTh), cortical surface area (CSA), gray matter volume (GMV), and mean curvature (MCu), were explored for discriminative analysis. Three feature selection methods, the independent sample t-test filtering, the sparse-constrained dimensionality reduction model (SCDRM), and the support vector machine-recursive feature elimination (SVM-RFE), were investigated to extract dominant regions with significant differences among the compared groups for classification using the SVM classifier. The results showed that the SVM-REF achieved the highest performance (most classifications with more than 92% accuracy), followed by the SCDRM, and the t-test. Especially, the surface area and gray volume matter exhibited prominent discriminative ability, and the performance of the SVM was improved significantly when the four cortical features were combined. Additionally, the dominant regions with higher classification weights were mainly located in temporal and frontal lobe, including the inferior temporal, entorhinal cortex, fusiform, parahippocampal cortex, middle frontal and frontal pole. It was demonstrated that the cortical features provided effective information to determine the abnormal anatomical pattern and the proposed method has the potential to improve the clinical diagnosis of the TLE.

Paper Details

Date Published: 8 February 2017
PDF: 6 pages
Proc. SPIE 10225, Eighth International Conference on Graphic and Image Processing (ICGIP 2016), 102252A (8 February 2017); doi: 10.1117/12.2266346
Show Author Affiliations
Chunren Lai, South China Univ. of Technology (China)
Shengwen Guo, South China Univ. of Technology (China)
Lina Cheng, Guangdong 999 Brain Hospital (China)
Wensheng Wang, Guangdong 999 Brain Hospital (China)
Kai Wu, South China Univ. of Technology (China)


Published in SPIE Proceedings Vol. 10225:
Eighth International Conference on Graphic and Image Processing (ICGIP 2016)
Yulin Wang; Tuan D. Pham; Vit Vozenilek; David Zhang; Yi Xie, Editor(s)

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