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Proceedings Paper

Detection of glycoprotein using fiber optic surface plasmon resonance sensors with boronic acid
Author(s): Fang Wang; Yang Zhang; Zigeng Liu; Siyu Qian; Yiying Gu; Zhenguo Jing; Changsen Sun; Wei Peng
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Paper Abstract

In this paper, we present a tilted fiber Bragg gratings (TFBG) based surface Plasmon resonance (SPR) label-free sensors with boronic acid derivative (ABA-PBA) as receptor molecule to detect glycoprotein with high sensitivity and selectivity. Tilted fiber Bragg gratings (TFBG) as a near infrared wavelengths detecting element can be able to excite a number of cladding modes whose properties can be detected accurately by measuring the variation of transmitted spectra. A 10° TFBG coated by 50nm gold film was manufactured to stimulate surface plasmon resonance on the surface of the sensor. The sensor was loaded with boronic acid derivative as the recognition molecule which has been widely used in various areas for the recognition matrix of diol-containing biomolecules. The proposed TFBG-SPR sensors exhibit good selectivity and repeatability with the protein concentration sensitivity up to 2.867dB/ (mg/ml) and the limit of detection was 2*10-5g/ml.

Paper Details

Date Published: 23 April 2017
PDF: 4 pages
Proc. SPIE 10323, 25th International Conference on Optical Fiber Sensors, 103233W (23 April 2017); doi: 10.1117/12.2265366
Show Author Affiliations
Fang Wang, Dalian Univ. of Technology (China)
Yang Zhang, Dalian Univ. of Technology (China)
Zigeng Liu, Dalian Univ. of Technology (China)
Siyu Qian, Dalian Univ. of Technology (China)
Yiying Gu, Dalian Univ. of Technology (China)
Zhenguo Jing, Dalian Univ. of Technology (China)
Changsen Sun, Dalian Univ. of Technology (China)
Wei Peng, Dalian Univ. of Technology (China)


Published in SPIE Proceedings Vol. 10323:
25th International Conference on Optical Fiber Sensors
Youngjoo Chung; Wei Jin; Byoungho Lee; John Canning; Kentaro Nakamura; Libo Yuan, Editor(s)

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