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Non-invasive characterization of normal and pathological tissues through dynamic infrared imaging in the hamster cheek pouch oral cancer model
Author(s): María S. Herrera; Andrea Monti Hughes; Natalia Salva; Claudio Padra; Amanda Schwint; Gustavo A. Santa Cruz
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Paper Abstract

Biomedical infrared thermography, a non-invasive and functional imaging method, provides information on the normal and abnormal status and response of tissues in terms of spatial and temporal variations in body infrared radiance. It is especially attractive in cancer research due to the hypervascular and hypermetabolic activity of solid tumors. Moreover, healthy tissues like skin or mucosa exposed to radiation can be examined since inflammation, changes in water content, exudation, desquamation, erosion and necrosis, between others, are factors that modify their thermal properties.

In this work we performed Dynamic Infrared Imaging (DIRI) to contribute to the understanding and evaluation of normal tissue, tumor and precancerous tissue response and radiotoxicity in an in vivo model, the hamster cheek pouch, exposed to Boron Neutron Capture Therapy. In this study, we particularly focused on the observation of temperature changes under forced transient conditions associated with mass moisture transfer in the tissue-air interface, in each tissue with or without treatment. We proposed a simple mathematical procedure that considerers the heat transfer from tissue to ambient through convection and evaporation to model the transient (exponential decay o recover) thermal study. The data was fitted to determined the characteristic decay and recovery time constants of the temperature as a function of time. Also this model allowed to explore the mass flux of moisture, as a degree of evaporation occurring on the tissue surface. Tissue thermal responses under provocation tests could be used as a non-invasive method to characterize tissue physiology.

Paper Details

Date Published: 5 May 2017
PDF: 19 pages
Proc. SPIE 10214, Thermosense: Thermal Infrared Applications XXXIX, 102140D (5 May 2017); doi: 10.1117/12.2264426
Show Author Affiliations
María S. Herrera, Ctr. de Tecnología de recursos Minerales y Cerámica (Argentina)
Andrea Monti Hughes, Comisión Nacional de Energía Atómica (Argentina)
Natalia Salva, CONICET (Argentina)
Comisión Nacional de Energía Atómica (Argentina)
Claudio Padra, CONICET (Argentina)
Comisión Nacional de Energía Atómica (Argentina)
Amanda Schwint, CONICET (Argentina)
Comisión Nacional de Energía Atómica (Argentina)
Gustavo A. Santa Cruz, Comisión Nacional de Energía Atómica (Argentina)


Published in SPIE Proceedings Vol. 10214:
Thermosense: Thermal Infrared Applications XXXIX
Paolo Bison; Douglas Burleigh, Editor(s)

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