Share Email Print
cover

Proceedings Paper

Magnetic nanotubes for drug delivery
Author(s): Mouli Ramasamy; Prashanth Shyam Kumar; Vijay K. Varadan
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Magnetic nanotubes hold the potential for neuroscience applications because of their capability to deliver chemicals or biomolecules and the feasibility of controlling the orientation or movement of these magnetic nanotubes by an external magnetic field thus facilitating directed growth of neurites. Therefore, we sought to investigate the effects of laminin treated magnetic nanotubes and external alternating magnetic fields on the growth of dorsal root ganglion (DRG) neurons in cell culture. Magnetic nanotubes were synthesized by a hydrothermal method and characterized to confirm their hollow structure, the hematite and maghemite phases, and the magnetic properties. DRG neurons were cultured in the presence of magnetic nanotubes under alternating magnetic fields. Electron microscopy showed a close interaction between magnetic nanotubes and the growing neurites Phase contrast microscopy revealed live growing neurons suggesting that the combination of the presence of magnetic nanotubes and the alternating magnetic field were tolerated by DRG neurons. The synergistic effect, from both laminin treated magnetic nanotubes and the applied magnetic fields on survival, growth and electrical activity of the DRG neurons are currently being investigated.

Paper Details

Date Published: 24 April 2017
PDF: 9 pages
Proc. SPIE 10167, Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017, 1016715 (24 April 2017); doi: 10.1117/12.2264367
Show Author Affiliations
Mouli Ramasamy, The Pennsylvania State Univ. (United States)
Prashanth Shyam Kumar, The Pennsylvania State Univ. (United States)
Vijay K. Varadan, The Pennsylvania State Univ. (United States)


Published in SPIE Proceedings Vol. 10167:
Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017
Vijay K. Varadan, Editor(s)

© SPIE. Terms of Use
Back to Top