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Proceedings Paper

The driving regulators of the connectivity protein network of brain malignancies
Author(s): Amirhessam Tahmassebi; Katja Pinker-Domenig; Georg Wengert; Marc Lobbes; Andreas Stadlbauer; Norelle C. Wildburger; Francisco J. Romero; Diego P. Morales; Encarnacion Castillo; Antonio Garcia; Guillermo Botella; Anke Meyer-Bäse
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Paper Abstract

An important problem in modern therapeutics at the proteomic level remains to identify therapeutic targets in a plentitude of high-throughput data from experiments relevant to a variety of diseases. This paper presents the application of novel modern control concepts, such as pinning controllability and observability applied to the glioma cancer stem cells (GSCs) protein graph network with known and novel association to glioblastoma (GBM). The theoretical frameworks provides us with the minimal number of "driver nodes", which are necessary, and their location to determine the full control over the obtained graph network in order to provide a change in the network’s dynamics from an initial state (disease) to a desired state (non-disease). The achieved results will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, to design and test novel therapeutic solutions.

Paper Details

Date Published: 16 May 2017
PDF: 8 pages
Proc. SPIE 10216, Smart Biomedical and Physiological Sensor Technology XIV, 1021605 (16 May 2017); doi: 10.1117/12.2263554
Show Author Affiliations
Amirhessam Tahmassebi, Florida State Univ. (United States)
Katja Pinker-Domenig, Florida State Univ. (United States)
Medical Univ. of Vienna (Austria)
Memorial Sloan-Kettering Cancer Ctr. (United States)
Georg Wengert, Medical Univ. of Vienna (Austria)
Marc Lobbes, Maastricht Univ. (Netherlands)
Andreas Stadlbauer, Univ. of Erlangen-Nürnberg (Germany)
Norelle C. Wildburger, Washington Univ. in St. Louis (United States)
Francisco J. Romero, Univ. de Granada (Spain)
Diego P. Morales, Univ. de Granada (Spain)
Encarnacion Castillo, Univ. de Granada (Spain)
Antonio Garcia, Univ. de Granada (Spain)
Guillermo Botella, Univ. Complutense de Madrid (Spain)
Anke Meyer-Bäse, Florida State Univ. (United States)
Maastricht Univ. (Netherlands)


Published in SPIE Proceedings Vol. 10216:
Smart Biomedical and Physiological Sensor Technology XIV
Brian M. Cullum; Douglas Kiehl; Eric S. McLamore, Editor(s)

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