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Proceedings Paper

Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards
Author(s): Jeeseong Hwang; Hyun-Jin Kim; Paul Lemaillet; Heidrun Wabnitz; Dirk Grosenick; Lin Yang; Thomas Gladytz; David McClatchy; David Allen; Kimberly Briggman; Brian Pogue
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Paper Abstract

We report on a procedure to build and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Controlled inclusion of light scattering titanium dioxide (TiO2) nanoparticles enables the creation of phantoms having tunable light scattering properties with reduced scattering coefficients consistent across different measurement platforms including an integrating sphere and a time-resolved diffuse optical spectroscopic system. Backscatter confocal microscopy is also used to characterize the shape and distribution of included TiO2 particles. The double integrating sphere and time-resolved diffuse spectroscopy were used to measure the reduced scattering coefficients of the phantoms. The results across different systems are in good agreement, suggesting that the PDMS/TiO2 composite is a promising tissue-mimicking material for developing standards useful to validate measurements by different devices for multiplatform and multi-laboratory tests.

Paper Details

Date Published: 15 March 2017
PDF: 6 pages
Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 1005603 (15 March 2017); doi: 10.1117/12.2263379
Show Author Affiliations
Jeeseong Hwang, National Institute of Standards and Technology (United States)
Hyun-Jin Kim, National Institute of Standards and Technology (United States)
Paul Lemaillet, National Institute of Standards and Technology (United States)
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Dirk Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
Lin Yang, Physikalisch-Technische Bundesanstalt (Germany)
Thomas Gladytz, Physikalisch-Technische Bundesanstalt (Germany)
David McClatchy, Thayer School of Engineering at Dartmouth (United States)
David Allen, National Institute of Standards and Technology (United States)
Kimberly Briggman, National Institute of Standards and Technology (United States)
Brian Pogue, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 10056:
Design and Quality for Biomedical Technologies X
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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