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Proceedings Paper

Optical properties of a paramagnetic metalloporphyrin hematoporphyrin monomethyl ether coordinated to divalent manganese metal ion
Author(s): Huimin Zhao; Lixin Zang; Guixiang Hu; Chenshan Guo
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Paper Abstract

Metalloporphyrins with paramagnetism are becoming research focus because their potential use in biomedical field as fluorescence probes and the magnetic resonance imaging (MRI) contrast agents. Divalent manganese metal ion (Mn2+) has a half-filled 3d shell with a strong paramagnetic effect. To investigate whether porphyrins coordinated to Mn2+ can serve as multiple functional probes, hematoporphyrin monomethyl ether coordinated to Mn2+ (Mn-HMME) was synthesized and its characterization, MRI enhancement property, luminescence property and photosensitivity were studied. Mn-HMME was characterized by UV-visible spectrum and Fourier transform infrared spectrum. It was found that the number of Q bands in the absorption spectrum of Mn-HMME reduced to two compared to free HMME. From the Fourier transform infrared spectrum of Mn-HMME, the characteristic infrared absorption peak of N-H bond in HMME at 970 cm-1 disappears, but the nitrogen-metal characteristic absorption peaks (1114 cm-1 and 1093 cm-1) were observed. The MRI of Mn-HMME indicates that Mn-HMME has relatively strong MRI enhancement effect. From luminescence spectroscopic analysis, the fluorescence emission of Mn-HMME was weaker than that of free HMME but still detectable. This may be caused by the energy transfer from free HMME to Mn2+. The test of photosensitivity of Mn- HMME denotes that the photosensitivity of Mn-HMME disappears. Our results indicate that Mn-HMME has the potential as a multiple functional probe in both fluorescence imaging and MRI.

Paper Details

Date Published: 28 February 2017
PDF: 5 pages
Proc. SPIE 10256, Second International Conference on Photonics and Optical Engineering, 102565B (28 February 2017); doi: 10.1117/12.2261087
Show Author Affiliations
Huimin Zhao, Shandong Normal Univ. (China)
Lixin Zang, Harbin Institute of Technology (China)
Guixiang Hu, Shandong Normal Univ. (China)
Chenshan Guo, Shandong Normal Univ. (China)

Published in SPIE Proceedings Vol. 10256:
Second International Conference on Photonics and Optical Engineering
Chunmin Zhang; Anand Asundi, Editor(s)

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