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Proceedings Paper

Image guided surgery using near-infrared fluorescence: road to clinical translation of novel probes for real time tumor visualization
Author(s): Charlotte E. S. Hoogstins; Henricus J. M. Handgraaf; Leonora S. F. Boogerd; Jacobus Burggraaf; Alexander L. Vahrmeijer
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Paper Abstract

Fluorescence imaging is a novel intraoperative technique for guiding oncologic surgeons toward radical tumor resections. Application of various fluorescent agents in exploratory clinical trials has already yielded promising results. The field of fluorescence imaging must now move beyond the proof-of-concept phase toward clinical application and implementation. This shift encompasses several hurdles, including standardization, advanced-phase study endpoints, regulatory affairs and routine implementation, which need to be addressed by the community in close collaboration with all stakeholders. These challenges, and the possible actions to overcome them and promote and accelerate clinical implementation of fluorescence imaging, are summarized in this paper.

Paper Details

Date Published: 8 February 2017
PDF: 6 pages
Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 100490X (8 February 2017); doi: 10.1117/12.2260520
Show Author Affiliations
Charlotte E. S. Hoogstins, Leiden Univ. Medical Ctr. (Netherlands)
Ctr. for Human Drug Research (Netherlands)
Henricus J. M. Handgraaf, Leiden Univ. Medical Ctr. (Netherlands)
Ctr. for Human Drug Research (Netherlands)
Leonora S. F. Boogerd, Leiden Univ. Medical Ctr. (Netherlands)
Ctr. for Human Drug Research (Netherlands)
Jacobus Burggraaf, Leiden Univ. Medical Ctr. (Netherlands)
Ctr. for Human Drug Research (Netherlands)
Alexander L. Vahrmeijer, Leiden Univ. Medical Ctr. (Netherlands)
Ctr. for Human Drug Research (Netherlands)


Published in SPIE Proceedings Vol. 10049:
Molecular-Guided Surgery: Molecules, Devices, and Applications III
Brian W. Pogue; Sylvain Gioux, Editor(s)

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