Share Email Print
cover

Proceedings Paper

Multivariate surface-based analysis of corpus callosum in patients with sickle cell disease
Author(s): Yaqiong Chai; Yi Lao; Yicen Li; Chaoran Ji; Sharon O'Neil; Yalin Wang; Natasha Lepore; John Wood
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Sickle cell disease (SCD) is a genetic hematological disease in which the hemoglobin molecule in red blood cells is abnormal. It is closely associated with many symptoms, including pain, anemia, chest syndrome and neurocognitive impairment. One of the most debilitating symptoms is elevated risk for cerebro-vascular accidents. The corpus callosum (CC), as the largest and most prominent white matter (WM) structure in the brain, can reflect the chronic cerebrovascular damage resulting from silent strokes or infarctions in asymptomatic SCD patients. While a lot of studies have reported WM alterations in this cohort, little is known about the shape deformation of the CC. Here we perform the first surface morphometry analysis of the CC in SCD patients using four different shape metrics on T1-weighted magnetic resonance images. We detect regional surface morphological differences in the CC between 11 patients and 10 healthy control subjects. Differences are located in the genu, posterior midbody and splenium, potentially casting light on the anatomical substrates underlying neuropsychological test differences between the SCD and control groups.

Paper Details

Date Published: 26 January 2017
PDF: 6 pages
Proc. SPIE 10160, 12th International Symposium on Medical Information Processing and Analysis, 101600A (26 January 2017); doi: 10.1117/12.2257399
Show Author Affiliations
Yaqiong Chai, Children's Hospital Los Angeles (United States)
The Univ. of Southern California (United States)
Yi Lao, Children's Hospital Los Angeles (United States)
The Univ. of Southern California (United States)
Yicen Li, The Univ. of Southern California (United States)
Chaoran Ji, The Univ. of Southern California (United States)
Sharon O'Neil, Children's Hospital Los Angeles (United States)
Yalin Wang, Arizona State Univ. (United States)
Natasha Lepore, Children's Hospital Los Angeles (United States)
The Univ. of Southern California (United States)
John Wood, Children's Hospital Los Angeles (United States)


Published in SPIE Proceedings Vol. 10160:
12th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva; Jorge Brieva; Ignacio Larrabide; , Editor(s)

© SPIE. Terms of Use
Back to Top