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Proceedings Paper

Nanophotonic interferometric immunosensors for label-free and real-time monitoring of chemical contaminants in marine environment
Author(s): B. Chocarro-Ruiz; S. Herranz; A. Fernández Gavela; L. M. Lechuga
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Paper Abstract

With the aim to prevent the oceans ecosystems degradation, there is an urgent need to develop portable sensing tools able to operate directly in the environment, avoiding the transportation of the ocean samples to analytical laboratories. To achieve this long-term objective, we describe here the work carried out to develop and characterize a multiplexed photonic immunosensor for the direct analysis of toxic chemical targets in marine samples. We have employed immunosensors based on photonic Bimodal Waveguide (BiMW) interferometric devices fabricated in silicon technologies combined with specific receptors and antibodies for the targeted chemical targets. Several procedures for the functionalization of the Si3N4 sensor surfaces have been evaluated based on wet silanization methods and further covalent receptor immobilization. The developed immunosensors, based on competitive inhibition assays, show LODs at μg/L or ng/L levels, depending on the analyzed chemical target.

Paper Details

Date Published: 3 May 2017
PDF: 6 pages
Proc. SPIE 10215, Advanced Environmental, Chemical, and Biological Sensing Technologies XIV, 1021503 (3 May 2017); doi: 10.1117/12.2256982
Show Author Affiliations
B. Chocarro-Ruiz, Institut Català de Nanociència i Nanotecnologia (ICN2) (Spain)
CIBER-BBN (Spain)
S. Herranz, Institut Català de Nanociència i Nanotecnologia (ICN2) (Spain)
CIBER-BBN (Spain)
A. Fernández Gavela, Institut Català de Nanociència i Nanotecnologia (ICN2) (Spain)
CIBER-BBN (Spain)
L. M. Lechuga, Institut Català de Nanociència i Nanotecnologia (ICN2) (Spain)
CIBER-BBN (Spain)


Published in SPIE Proceedings Vol. 10215:
Advanced Environmental, Chemical, and Biological Sensing Technologies XIV
Tuan Vo-Dinh; Robert A. Lieberman, Editor(s)

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