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Proceedings Paper

Variable clustering reveals associations between subcortical brain volume and cognitive changes in pediatric traumatic brain injury
Author(s): Artemis Zavaliangos-Petropulu; Emily L. Dennis; Greg Ver Steeg; Talin Babikian; Richard Mink; Christopher Babbitt; Jeffrey Johnson; Christopher C. Giza; Robert F. Asarnow; Paul M. Thompson
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Paper Abstract

Outcomes after traumatic brain injury (TBI) are variable and only partially predicted by acute injury factors. With rich datasets, we can examine how numerous factors – cognitive scores, acute injury variables, demographic variables, and brain imaging variables – are interrelated and aid in outcome prediction. To help study this rich data, we applied CorEx, a novel method for unsupervised machine learning. CorEx decodes the hierarchical structure, identifying latent causes of dependence in the data. It groups predictor variables based on their joint information and inter-dependence. We examined 21 TBI patients 2-5 months post-injury along with healthy controls; both groups were assessed again 12 months later. Although we were limited in the number of participants, this tool for exploratory analysis found potential relationships between change in cognitive scores over the 12-month period and baseline brain volumes. Certain regional brain volumes measured post-injury could serve as predictors of patient recovery. As future planned analyses will examine greater sample sizes, we hope to perform follow-up statistical analysis of variables identified by CorEx in independent data.

Paper Details

Date Published: 26 January 2017
PDF: 8 pages
Proc. SPIE 10160, 12th International Symposium on Medical Information Processing and Analysis, 101600V (26 January 2017); doi: 10.1117/12.2256977
Show Author Affiliations
Artemis Zavaliangos-Petropulu, Keck Medicine of USC (United States)
Emily L. Dennis, Keck Medicine of USC (United States)
Greg Ver Steeg, The Univ. of Southern California (United States)
Talin Babikian, Univ. of California, Los Angeles (United States)
Richard Mink, Harbor-UCLA Medical Ctr. (United States)
Los Angeles BioMedical Research Institute (United States)
Christopher Babbitt, Miller Children's Hospital (United States)
Jeffrey Johnson, LAC+USC Medical Ctr. (United States)
Christopher C. Giza, UCLA Brain Injury Research Ctr. (United States)
Robert F. Asarnow, Univ. of California, Los Angeles (United States)
Paul M. Thompson, Keck Medicine of USC (United States)
Univ. of California, Los Angeles (United States)
The Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 10160:
12th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva; Jorge Brieva; Ignacio Larrabide; , Editor(s)

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