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Proceedings Paper

Large-scale classification of major depressive disorder via distributed Lasso
Author(s): Dajiang Zhu; Qingyang Li; Brandalyn C. Riedel; Neda Jahanshad; Derrek P. Hibar; Ilya M. Veer; Henrik Walter; Lianne Schmaal; Dick J. Veltman; Dominik Grotegerd; Udo Dannlowski; Matthew D. Sacchet; Ian H. Gotlib; Jieping Ye; Paul M. Thompson
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Paper Abstract

Compared to many neurological disorders, for which imaging biomarkers are often available, there are no accepted imaging biomarkers to assist in the diagnosis of major depressive disorder (MDD). One major barrier to understanding MDD has been the lack of a practical and efficient platform for collaborative efforts across multiple data centers; integrating the knowledge from different centers should make it easier to identify characteristic measures that are consistently associated with the illness. Here we applied our newly developed “distributed Lasso” method to brain MRI data from multiple centers to perform feature selection and classification. Over 1,000 participants were involved in the study; our results indicate the potential of the proposed framework to enable large-scale collaborative data analysis in the future.

Paper Details

Date Published: 26 January 2017
PDF: 6 pages
Proc. SPIE 10160, 12th International Symposium on Medical Information Processing and Analysis, 101600Y (26 January 2017); doi: 10.1117/12.2256935
Show Author Affiliations
Dajiang Zhu, The Univ. of Southern California (United States)
Qingyang Li, Univ. of Michigan (United States)
Brandalyn C. Riedel, The Univ. of Southern California (United States)
Neda Jahanshad, The Univ. of Southern California (United States)
Derrek P. Hibar, The Univ. of Southern California (United States)
Ilya M. Veer, Charité Universitätsmedizin Berlin (Germany)
Henrik Walter, Charité Universitätsmedizin Berlin (Germany)
Lianne Schmaal, VU Univ. Medical Ctr. (Netherlands)
The National Ctr. of Excellence in Youth Mental Health (Australia)
The Univ. of Melbourne (Australia)
Dick J. Veltman, VU Univ. Medical Ctr. (Netherlands)
Dominik Grotegerd, Univ. of Muenster (Germany)
Udo Dannlowski, Univ. of Muenster (Germany)
Matthew D. Sacchet, Stanford Univ. (United States)
Ian H. Gotlib, Stanford Univ. (United States)
Jieping Ye, Univ. of Michigan (United States)
Paul M. Thompson, The Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 10160:
12th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva; Jorge Brieva; Ignacio Larrabide; , Editor(s)

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