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Proceedings Paper

Tract-based spectroscopy to investigate pediatric brain trauma
Author(s): Emily L. Dennis; Jeffry R. Alger; Talin Babikian; Faisal Rashid; Julio E. Villalon-Reina; Richard Mink; Christopher Babbitt; Jeffrey L. Johnson; Christopher C. Giza; Robert F. Asarnow; Paul M. Thompson
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Paper Abstract

Traumatic brain injury (TBI) causes extensive damage to the white matter (WM) of the brain, which can be evaluated with diffusion-weighted magnetic resonance imaging (dMRI). Diffusion MRI can be used to map the WM tracts and their integrity, but offers limited understanding of the biochemical basis of any differences. Magnetic resonance spectroscopy (MRS) measures neural metabolites that reflect neuronal health, inflammation, demyelination, and other consequences of TBI. We combined whole-brain MRS with dMRI to investigate WM dysfunction following pediatric TBI, using “tract-based spectroscopy”. Deficits in N-acetylaspartate (NAA) correspond to regions of deficits in WM integrity, but choline showed minimal overlap with WM deficits. NAA is a marker of neuronal health, while choline is an inflammatory marker. A partial F-test showed that MRS measures improved our ability to predict long-term cognitive function. This is the first paper to combine MRS with dMRI-derived tracts on a whole-brain scale, offering insights into the biochemical correlates of WM tract dysfunction, following injury and potentially in other WM disorders.

Paper Details

Date Published: 26 January 2017
PDF: 7 pages
Proc. SPIE 10160, 12th International Symposium on Medical Information Processing and Analysis, 1016019 (26 January 2017); doi: 10.1117/12.2256886
Show Author Affiliations
Emily L. Dennis, The Univ. of Southern California (United States)
Jeffry R. Alger, Univ. of California, Los Angeles (United States)
Talin Babikian, Univ. of California, Los Angeles (United States)
Mattel Children's Hospital (United States)
Faisal Rashid, The Univ. of Southern California (United States)
Julio E. Villalon-Reina, The Univ. of Southern California (United States)
Richard Mink, Harbor-UCLA Medical Ctr. (United States)
Los Angeles Biomedical Research Institute (United States)
Christopher Babbitt, Miller Children's Hospital (United States)
Jeffrey L. Johnson, LAC+USC Medical Ctr. (United States)
Christopher C. Giza, Mattel Children's Hospital (United States)
Robert F. Asarnow, Univ. of California, Los Angeles (United States)
Paul M. Thompson, The Univ. of Southern California (United States)
Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 10160:
12th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva; Jorge Brieva; Ignacio Larrabide; , Editor(s)

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