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Low-level light treatment ameliorates immune thrombocytopenia
Author(s): Jingke Yang; Qi Zhang; Mei X. Wu
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Paper Abstract

Immune thrombocytopenia (ITP) is an immune-mediated acquired bleeding disorder characterized by abnormally low platelet counts. We reported here the ability of low-level light treatment (LLLT) to alleviate ITP in mice. The treatment is based on noninvasive whole body illumination 30 min a day for a few consecutive days by near infrared light (830 nm) transmitted by an array of light-emitting diodes (LEDs). LLLT significantly lifted the nadir of platelet counts and restored tail bleeding time when applied to two passive ITP models induced by anti-CD41 antibody. The anti-platelet antibody hindered megakaryocyte differentiation from the progenitors, impaired proplatelet and platelet formation, and induced apoptosis of platelets. These adverse effects of anti-CD41 antibody were all mitigated by LLLT to varying degrees, owing to its ability to enhance mitochondrial biogenesis and activity in megakaryocytes and preserve mitochondrial functions in platelets in the presence of the antibody. The observations argue not only for contribution of mitochondrial stress to the pathology of ITP, but also clinical potentials of LLLT as a safe, simple, and cost-effective modality of ITP.

Paper Details

Date Published: 17 February 2017
PDF: 16 pages
Proc. SPIE 10048, Mechanisms of Photobiomodulation Therapy XII, 100480E (17 February 2017); doi: 10.1117/12.2256303
Show Author Affiliations
Jingke Yang, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Affiliated Cancer Hospital of Zhengzhou Univ. (China)
Qi Zhang, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Mei X. Wu, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 10048:
Mechanisms of Photobiomodulation Therapy XII
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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