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Proceedings Paper

Photoacoustic imaging of hepatocellular carcinoma targeting gold nanoshells (Conference Presentation)
Author(s): Quan Zhou; Yan Chen; Zhao Li; Juan Zhou; Xiyu Duan; Thomas D. Wang
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Paper Abstract

Plasmonic gold nanoshell (GNS) probe penetrates into tumors for deep imaging, enables superior photoacoustic contrast. Glypican-3 (GPC3) specific peptide (Kd = 71 nM) conjugated gold nanoshell (λabs=770nm) was used to detect HCC xenograft tumors in mice with photoacoustic imaging. This targeting probe demonstrated tumor uptake after 1 hr and cleared in 12 hrs. Images at a mean (±SD) depth of 9.7±1.4 mm from 0 to 2.1 cm beneath the skin revealed increased PA signal from tumors. Highest tumor uptake and tumor to normal tissue ratio occurred at 2 hrs post injection (T/B = 4.45±0.22, n = 8). Molecular targeting GNS showed potential as a simple, effective and rapid technique for noninvasive in vivo monitoring HCC tumor growth and GPC3 expression.

Paper Details

Date Published: 24 April 2017
PDF: 1 pages
Proc. SPIE 10079, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX, 1007907 (24 April 2017); doi: 10.1117/12.2255917
Show Author Affiliations
Quan Zhou, Univ. of Michigan (United States)
Yan Chen, Univ. of Michigan (United States)
Zhao Li, Peking Univ. People's Hospital (China)
Juan Zhou, Univ. of Michigan (United States)
Xiyu Duan, Univ. of Michigan (United States)
Thomas D. Wang, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 10079:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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