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Proceedings Paper

Preliminary assessment of a hysteroscopic fallopian tube heat and biomaterial technology for permanent female sterilization
Author(s): Prajan Divakar; B. Stuart Trembly; Karen L. Moodie; P. Jack Hoopes; Ulrike G. K. Wegst
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Paper Abstract

Recent failures in hysteroscopic female sterilization procedures have brought into question the implantation of nonresorbable metal devices into the fallopian tubes due to long-term risks such as migration, fragmentation, and tubal perforation. The goal of this study is to assess whether a porous, biodegradable implant can be deposited into the fallopian tube lumen with or without a local mild heat treatment to generate a safe and permanent fallopian tube occlusion/sterilization event. The technologies investigated included freeze-cast collagen-based scaffolds and magnetic nanoparticle (MNP) based scaffolds. In vitro assessment of iron oxide MNP-based scaffolds was performed to determine the absorption rate density (ARD); subsequent computational modeling quantified the thermal in vivo steady state temperature as a function of tubal radius for treatment planning. For collagen-based scaffolds, in vivo testing was performed to study the biocompatibility in a mouse flank model, followed by implantation into an in vivo anestrus feline uterine horn (animal model for the fallopian tube). Biological responses were studied histopathologically. Uterine horn patency was assessed via radiographic imaging. Preliminary studies suggest the MNP-impregnated scaffold and a safe, noninvasive AMF excitation field have potential to generate a sufficient focal fallopian tube thermal dose to create a fibrotic healing event and ultimately, permanent tubal occlusion.

Paper Details

Date Published: 22 February 2017
PDF: 11 pages
Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 100660A (22 February 2017); doi: 10.1117/12.2255843
Show Author Affiliations
Prajan Divakar, Thayer School of Engineering at Dartmouth (United States)
B. Stuart Trembly, Thayer School of Engineering at Dartmouth (United States)
Karen L. Moodie, Geisel School of Medicine at Dartmouth (United States)
P. Jack Hoopes, Thayer School of Engineering at Dartmouth (United States)
Geisel School of Medicine at Dartmouth (United States)
Ulrike G. K. Wegst, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 10066:
Energy-based Treatment of Tissue and Assessment IX
Thomas P. Ryan, Editor(s)

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