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Proceedings Paper

Low Intensity Pulsed Ultrasound (LIPUS) for the treatment of intervertebral disc degeneration
Author(s): Devante Horne; Peter Jones; Vasant Salgaonkar; Matt Adams; B. Arda Ozilgen; Peter Zahos; Xinyan Tang; Ellen Liebenberg; Dezba Coughlin; Jeffrey Lotz; Chris Diederich
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Paper Abstract

Discogenic back pain presents a major public health issue, with current therapeutic interventions limited to short-term symptom relief without providing regenerative remedies for diseased intervertebral discs (IVD). Many of these interventions are invasive and can diminish the biomechanical integrity of the IVDs. Low intensity pulsed ultrasound (LIPUS) is a potential treatment option that is both non-invasive and regenerative. LIPUS has been shown to be a clinically effective method for the enhancement of wound and fracture healing. Recent in vitro studies have shown that LIPUS stimulation induces an upregulation functional matrix proteins and downregulation of inflammatory factors in cultured IVD cells. However, we do not know the effects of LIPUS on an in vivo model for intervertebral disc degeneration. The objective of this study was to show technical feasibility of building a LIPUS system that can target the rat tail IVD and apply this setup to a model for acute IVD degeneration. A LIPUS exposimetry system was built using a 1.0 MHz planar transducer and custom housing. Ex vivo intensity measurements demonstrated LIPUS delivery to the center of the rat tail IVD. Using an established stab-incision model for disc degeneration, LIPUS was applied for 20 minutes daily for five days. For rats that displayed a significant injury response, LIPUS treatment caused significant upregulation of Collagen II and downregulation of Tumor Necrosis Factor – α gene expression. Our preliminary studies indicate technical feasibility of targeted delivery of ultrasound to a rat tail IVD for studies of LIPUS biological effects.

Paper Details

Date Published: 22 February 2017
PDF: 7 pages
Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 1006609 (22 February 2017); doi: 10.1117/12.2255761
Show Author Affiliations
Devante Horne, Univ. of California, Berkeley (United States)
Univ. of California, San Francisco (United States)
Peter Jones, Univ. of California, San Francisco (United States)
Vasant Salgaonkar, Univ. of California, San Francisco (United States)
Matt Adams, Univ. of California, San Francisco (United States)
B. Arda Ozilgen, Univ. of California, Berkeley (United States)
Univ. of California, San Francisco (United States)
Peter Zahos, Univ. of California, San Francisco (United States)
Xinyan Tang, Univ. of California, San Francisco (United States)
Ellen Liebenberg, Univ. of California San Francisco (United States)
Dezba Coughlin, Univ. of California, San Francisco (United States)
Jeffrey Lotz, Univ. of California, San Francisco (United States)
Chris Diederich, Univ. of California, San Francisco (United States)


Published in SPIE Proceedings Vol. 10066:
Energy-based Treatment of Tissue and Assessment IX
Thomas P. Ryan, Editor(s)

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