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Novel fluorescence-based POCT platform for therapeutic drug monitoring in transplanted patients (Conference Presentation)
Author(s): Francesco Baldini; Chiara Berrettoni; Ambra Giannetti; Sara Tombelli; Cosimo Trono; Giampiero Porro; Romeo Bernini; Immacolata Angelica Grimaldi; Genni Testa; Gianluca Persichetti; Claudia Gärtner; Holger Becker; Marcel Berner; Markus B. Schubert; Mark T. O'Connell; Daniel Carney; Guillermo Orellana; Ana B. Descalzo; Francesca Salis; Paulo P. Freitas; Peter B Luppa; Heike Bittersohl; Günter Gauglitz; Urs Hilbig; Kathrin Freudenberger
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Paper Abstract

A novel therapeutic drug monitoring point of care testing (POCT) optical device for the detection of immunosuppressants in transplanted patients was designed and tested, with the body interface constituted by an intravascular microdialysis catheter (MicroEye®) which provides the dialysate as clinical sample. An optical biochip with 10 microchannels, based on total internal reflection fluorescence (TIRF), enables the frequent measurement of immunosuppressants. Heterogeneous competitive immunoassays for the detection of mycophenolic acid, tacrolimus and cyclosporine A are implemented on the different microchannels, with the derivative of the immunosuppressants immobilised on the bottom part of the micro-channels.

Paper Details

Date Published: 24 April 2017
PDF: 1 pages
Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 100720C (24 April 2017); doi: 10.1117/12.2255623
Show Author Affiliations
Francesco Baldini, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Chiara Berrettoni, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Ambra Giannetti, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Sara Tombelli, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Cosimo Trono, Istituto di Fisica Applicata "Nello Carrara" (Italy)
Giampiero Porro, Datamed S.r.L. (Italy)
Romeo Bernini, Istituto per il Rilevamento Elettromagnetico dell'Ambiente (Italy)
Immacolata Angelica Grimaldi, Istituto per il Rilevamento Elettromagnetico dell'Ambiente (Italy)
Genni Testa, Istituto per il Rilevamento Elettromagnetico dell'Ambiente (Italy)
Gianluca Persichetti, Istituto per il Rilevamento Elettromagnetico dell'Ambiente (Italy)
Claudia Gärtner, microfluidic ChipShop GmbH (Germany)
Holger Becker, microfluidic ChipShop GmbH (Germany)
Marcel Berner, Institut für Photovoltaik, Univ. Stuttgart (Germany)
Markus B. Schubert, Institute for Photovoltaics, Univ. of Stuttgart (Germany)
Mark T. O'Connell, Probe Scientific Ltd. (United Kingdom)
Daniel Carney, Probe Scientific Ltd. (United Kingdom)
Guillermo Orellana, Univ. Complutense de Madrid (Spain)
Ana B. Descalzo, Univ. Complutense de Madrid (Spain)
Francesca Salis, Univ. Complutense de Madrid (Spain)
Paulo P. Freitas, INESC MN (Portugal)
Peter B Luppa, Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der TU München (Germany)
Heike Bittersohl, Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der TU München (Germany)
Günter Gauglitz, Institut für Physikalische und Theoretische Chemie, Eberhard Karls Univ. Tübingen (Germany)
Urs Hilbig, Institut für Physikalische und Theoretische Chemie, Eberhard Karls Univ. Tübingen (Germany)
Kathrin Freudenberger, Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der TU München (Germany)
Institut für Physikalische und Theoretische Chemie, Eberhard Karls Univ. Tübingen (Germany)


Published in SPIE Proceedings Vol. 10072:
Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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