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Proceedings Paper

Investigation of the benefit of adaptive optics optical coherence tomography angiography for the human retina (Conference Presentation)
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Paper Abstract

In this work we investigate the benefits of using optical coherence tomography angiography (OCTA) in combination with adaptive optics (AO) technology. It has been demonstrated that the contrast of vessels and small capillaries can be greatly enhanced by the use of OCTA. Moreover, small capillaries that are below the transverse resolution of the ophthalmic instrument can be detected. This opens unique opportunities for diagnosing retinal diseases. However, there are some limitations of this technology such as shadowing artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density can be misleading. To overcome these limitations we applied the OCT angiography technique to images recorded with AO-OCT. Due to the higher collection efficiency of AO-OCT in comparison with standard OCT an increased intensity contrast of vasculature can be seen. Using AO-OCTA the contrast of the vasculature to the surrounding static tissue is further increased. The improved transverse resolution and the reduced depth of focus of the AO-OCT greatly reduce shadowing artifacts allowing for a correct differentiation and segmentation of different vascular layers of the inner retina. The method is investigated in healthy volunteers and in patients with diabetic retinopathy.

Paper Details

Date Published: 19 April 2017
PDF: 1 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100530J (19 April 2017); doi: 10.1117/12.2254768
Show Author Affiliations
Matthias Salas, Medizinische Univ. Wien (Austria)
Marco Augustin, Medizinische Univ. Wien (Austria)
Laurin Ginner, Medizinische Univ. Wien (Austria)
Abhishek Kumar, Medizinische Univ. Wien (Austria)
Bernhard Baumann, Medizinische Univ. Wien (Austria)
Rainer A. Leitgeb, Medizinische Univ. Wien (Austria)
Wolfgang Drexler, Medizinische Univ. Wien (Austria)
Sonja Prager, Medizinische Univ. Wien (Austria)
Julia Hafner, Medizinische Univ Wien (Austria)
Ursula Schmidt-Erfurth, Medizinische Univ. Wien (Austria)
Michael Pircher, Medizinische Univ. Wien (Austria)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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