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Proceedings Paper

Deep learning and three-compartment breast imaging in breast cancer diagnosis
Author(s): Karen Drukker; Benjamin Q. Huynh; Maryellen L. Giger; Serghei Malkov; Jesus I. Avila; Bo Fan; Bonnie Joe; Karla Kerlikowske; Jennifer S. Drukteinis; Leila Kazemi; Malesa M. Pereira; John Shepherd
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Paper Abstract

We investigated whether deep learning has potential to aid in the diagnosis of breast cancer when applied to mammograms and biologic tissue composition images derived from three-compartment (3CB) imaging. The dataset contained diagnostic mammograms and 3CB images (water, lipid, and protein content) of biopsy-sampled BIRADS 4 and 5 lesions in 195 patients. In 58 patients, the lesion manifested as a mass (13 malignant vs. 45 benign), in 87 as microcalcifications (19 vs. 68), and in 56 as (focal) asymmetry or architectural distortion (11 vs. 45). Six patients had both a mass and calcifications. For each mammogram and corresponding 3CB images, a 128x128 region of interest containing the lesion was selected by an expert radiologist and used directly as input to a deep learning method pretrained on a very large independent set of non-medical images. We used a nested leave-one-out-by-case (patient) model selection and classification protocol. The area under the ROC curve (AUC) for the task of distinguishing between benign and malignant lesions was used as performance metric. For the cases with mammographic masses, the AUC increased from 0.83 (mammograms alone) to 0.89 (mammograms+3CB, p=.162). For the microcalcification and asymmetry/architectural distortion cases the AUC increased from 0.84 to 0.91 (p=.116) and from 0.61 to 0.87 (p=.006), respectively. Our results indicate great potential for the application of deep learning methods in the diagnosis of breast cancer and additional knowledge of the biologic tissue composition appeared to improve performance, especially for lesions mammographically manifesting as asymmetries or architectural distortions.

Paper Details

Date Published: 3 March 2017
PDF: 6 pages
Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 101341F (3 March 2017); doi: 10.1117/12.2254516
Show Author Affiliations
Karen Drukker, The Univ. of Chicago (United States)
Benjamin Q. Huynh, The Univ. of Chicago (United States)
Maryellen L. Giger, The Univ. of Chicago (United States)
Serghei Malkov, Univ. of San Francisco (United States)
Jesus I. Avila, Univ. of San Francisco (United States)
Bo Fan, Univ. of San Francisco (United States)
Bonnie Joe, Univ. of San Francisco (United States)
Karla Kerlikowske, Univ. of San Francisco (United States)
Jennifer S. Drukteinis, H. Lee Moffitt Cancer Ctr. & Research Institute (United States)
Leila Kazemi, Univ. of San Francisco (United States)
Malesa M. Pereira, H. Lee Moffitt Cancer Ctr. & Research Institute (United States)
John Shepherd, Univ. of San Francisco (United States)


Published in SPIE Proceedings Vol. 10134:
Medical Imaging 2017: Computer-Aided Diagnosis
Samuel G. Armato; Nicholas A. Petrick, Editor(s)

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