Share Email Print
cover

Proceedings Paper

Use of patient specific 3D printed neurovascular phantoms to evaluate the clinical utility of a high resolution x-ray imager
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Modern 3D printing technology can fabricate vascular phantoms based on an actual human patient with a high degree of precision facilitating a realistic simulation environment for an intervention. We present two experimental setups using 3D printed patient-specific neurovasculature to simulate different disease anatomies.

To simulate the human neurovasculature in the Circle of Willis, patient-based phantoms with aneurysms were 3D printed using a Objet Eden 260V printer. Anthropomorphic head phantoms and a human skull combined with acrylic plates simulated human head bone anatomy and x-ray attenuation. For dynamic studies the 3D printed phantom was connected to a pulsatile flow loop with the anthropomorphic phantom underneath. By combining different 3D printed phantoms and the anthropomorphic phantoms, different patient pathologies can be simulated. For static studies a 3D printed neurovascular phantom was embedded inside a human skull and used as a positional reference for treatment devices such as stents. To simulate tissue attenuation acrylic layers were added. Different combinations can simulate different patient treatment procedures.

The Complementary-Metal-Oxide-Semiconductor (CMOS) based High Resolution Fluoroscope (HRF) with 75μm pixels offers an advantage over the state-of-the-art 200 μm pixel Flat Panel Detector (FPD) due to higher Nyquist frequency and better DQE performance. Whether this advantage is clinically useful during an actual clinical neurovascular intervention can be addressed by qualitatively evaluating images from a cohort of various cases performed using both detectors. The above-mentioned method can offer a realistic substitute for an actual clinical procedure. Also a large cohort of cases can be generated and used for a HRF clinical utility determination study.

Paper Details

Date Published: 13 March 2017
PDF: 9 pages
Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, 101370I (13 March 2017); doi: 10.1117/12.2254390
Show Author Affiliations
S. V. Setlur Nagesh, Toshiba Stroke and Vascular Research Ctr., The Univ. of Buffalo (United States)
M. Russ, Toshiba Stroke and Vascular Research Ctr., The Univ. of Buffalo (United States)
C. N. Ionita, Toshiba Stroke and Vascular Research Ctr., The Univ. of Buffalo (United States)
D. Bednarek, Toshiba Stroke and Vascular Research Ctr., The Univ. of Buffalo (United States)
S. Rudin, Toshiba Stroke and Vascular Research Ctr., The Univ. of Buffalo (United States)


Published in SPIE Proceedings Vol. 10137:
Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging
Andrzej Krol; Barjor Gimi, Editor(s)

© SPIE. Terms of Use
Back to Top