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Proceedings Paper

Early classification of Alzheimer's disease using hippocampal texture from structural MRI
Author(s): Kun Zhao; Yanhui Ding; Pan Wang; Xuejiao Dou; Bo Zhou; Hongxiang Yao; Ningyu An; Yongxin Zhang; Xi Zhang; Yong Liu
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Paper Abstract

Convergent evidence has been collected to support that Alzheimer’s disease (AD) is associated with reduction in hippocampal volume based on anatomical magnetic resonance imaging (MRI) and impaired functional connectivity based on functional MRI. Radiomics texture analysis has been previously successfully used to identify MRI biomarkers of several diseases, including AD, mild cognitive impairment and multiple sclerosis. In this study, our goal was to determine if MRI hippocampal textures, including the intensity, shape, texture and wavelet features, could be served as an MRI biomarker of AD. For this purpose, the texture marker was trained and evaluated from MRI data of 48 AD and 39 normal samples. The result highlights the presence of hippocampal texture abnormalities in AD, and the possibility that texture may serve as a neuroimaging biomarker for AD.

Paper Details

Date Published: 13 March 2017
PDF: 7 pages
Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, 101372E (13 March 2017); doi: 10.1117/12.2254198
Show Author Affiliations
Kun Zhao, Shandong Normal Univ. (China)
Yanhui Ding, Shandong Normal Univ. (China)
Pan Wang, Chinese PLA General Hospital (China)
Xuejiao Dou, Institute of Automation (China)
Univ. of Chinese Academy of Sciences (China)
Bo Zhou, Chinese PLA General Hospital (China)
Hongxiang Yao, Chinese PLA General Hospital (China)
Ningyu An, Chinese PLA General Hospital (China)
Yongxin Zhang, Shandong Normal Univ. (China)
Xi Zhang, Chinese PLA General Hospital (China)
Yong Liu, Institute of Automation (China)
Univ. of Chinese Academy of Sciences (China)


Published in SPIE Proceedings Vol. 10137:
Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging
Andrzej Krol; Barjor Gimi, Editor(s)

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