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Iterative image reconstruction in elastic inhomogenous media with application to transcranial photoacoustic tomography
Author(s): Joemini Poudel; Thomas P. Matthews; Kenji Mitsuhashi; Alejandro Garcia-Uribe; Lihong V. Wang; Mark A. Anastasio
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Paper Abstract

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the photoacoustically induced initial pressure distribution within tissue. The PACT reconstruction problem corresponds to a time-domain inverse source problem, where the initial pressure distribution is recovered from the measurements recorded on an aperture outside the support of the source. A major challenge in transcranial PACT brain imaging is to compensate for aberrations in the measured data due to the propagation of the photoacoustic wavefields through the skull. To properly account for these effects, a wave equation-based inversion method should be employed that can model the heterogeneous elastic properties of the medium. In this study, an iterative image reconstruction method for 3D transcranial PACT is developed based on the elastic wave equation. To accomplish this, a forward model based on a finite-difference time-domain discretization of the elastic wave equation is established. Subsequently, gradient-based methods are employed for computing penalized least squares estimates of the initial source distribution that produced the measured photoacoustic data. The developed reconstruction algorithm is validated and investigated through computer-simulation studies.

Paper Details

Date Published: 13 March 2017
PDF: 7 pages
Proc. SPIE 10139, Medical Imaging 2017: Ultrasonic Imaging and Tomography, 101390C (13 March 2017); doi: 10.1117/12.2254141
Show Author Affiliations
Joemini Poudel, Washington Univ. in St. Louis (United States)
Thomas P. Matthews, Washington Univ. in St. Louis (United States)
Kenji Mitsuhashi, Washington Univ. in St. Louis (United States)
Alejandro Garcia-Uribe, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Mark A. Anastasio, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 10139:
Medical Imaging 2017: Ultrasonic Imaging and Tomography
Neb Duric; Brecht Heyde, Editor(s)

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