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Proceedings Paper

Characterization of nonlinear elasticity for biological tissue using quantitative optical coherence elastography
Author(s): Yi Qiu; Farzana R. Zaki; Namas Chandra; Shawn A. Chester; Xuan Liu
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Paper Abstract

We developed a quantitative optical coherence elastography (qOCE) system for nonlinear mechanical characterization of biological tissues. The fiber-optic probe of the qOCE system had an integrated Fabry-Perot force sensor. To perform mechanical characterization, the tissue was compressed uniaxially by the fiber-optic probe of the qOCE system. Using the optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to simultaneously quantify the force exerted to the tissue and the displacement of tissue. The quantification of the force was critical for accurate assessment of the elastic behavior of tissue, because most biological tissues have nonlinear elastic behavior. We performed qOCE characterization on tissue mimicking phantoms and biological tissues. Our results demonstrated the capability of the qOCE system for linear and nonlinear assessment of tissue elasticity.

Paper Details

Date Published: 17 February 2017
PDF: 4 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005324 (17 February 2017); doi: 10.1117/12.2254042
Show Author Affiliations
Yi Qiu, New Jersey Institute of Technology (United States)
Farzana R. Zaki, New Jersey Institute of Technology (United States)
Namas Chandra, New Jersey Institute of Technology (United States)
Shawn A. Chester, New Jersey Institute of Technology (United States)
Xuan Liu, New Jersey Institute of Technology (United States)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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