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Blood flow measurement using digital subtraction angiography for assessing hemodialysis access function
Author(s): Nischal Koirala; Randolph M. Setser; Jennifer Bullen; Gordon McLennan
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Paper Abstract

Blood flow rate is a critical parameter for diagnosing dialysis access function during fistulography where a flow rate of 600 ml/min in arteriovenous graft or 400-500 ml/min in arteriovenous fistula is considered the clinical threshold for fully functioning access. In this study, a flow rate computational model for calculating intra-access flow to evaluate dialysis access patency was developed and validated in an in vitro set up using digital subtraction angiography. Flow rates were computed by tracking the bolus through two regions of interest using cross correlation (XCOR) and mean arrival time (MAT) algorithms, and correlated versus an in-line transonic flow meter measurement. The mean difference (mean ± standard deviation) between XCOR and in-line flow measurements for in vitro setup at 3, 6, 7.5 and 10 frames/s was 118±63; 37±59; 31±31; and 46±57 ml/min respectively while for MAT method it was 86±56; 57±72; 35±85; and 19±129 ml/min respectively. The result of this investigation will be helpful for selecting candidate algorithms while blood flow computational tool is developed for clinical application.

Paper Details

Date Published: 13 March 2017
PDF: 15 pages
Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, 101370J (13 March 2017); doi: 10.1117/12.2253929
Show Author Affiliations
Nischal Koirala, Cleveland State Univ. (United States)
The Cleveland Clinic (United States)
Randolph M. Setser, Siemens Medical Solutions USA, Inc. (United States)
Jennifer Bullen, The Cleveland Clinic (United States)
Gordon McLennan, The Cleveland Clinic (United States)


Published in SPIE Proceedings Vol. 10137:
Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging
Andrzej Krol; Barjor Gimi, Editor(s)

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