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Proceedings Paper

Structural and functional imaging for vascular targeted photodynamic therapy
Author(s): Buhong Li; Ying Gu; Brian C. Wilson
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Paper Abstract

Vascular targeted photodynamic therapy (V-PDT) has been widely used for the prevention or treatment of vascular-related diseases, such as localized prostate cancer, wet age-related macular degeneration, port wine stains, esophageal varices and bleeding gastrointestinal mucosal lesions. In this study, the fundamental mechanisms of vascular responses during and after V-PDT will be introduced. Based on the V-PDT treatment of blood vessels in dorsal skinfold window chamber model, the structural and functional imaging, which including white light microscopy, laser speckle imaging, singlet oxygen luminescence imaging, and fluorescence imaging for evaluating vascular damage will be presented, respectively. The results indicate that vessel constriction and blood flow dynamics could be considered as the crucial biomarkers for quantitative evaluation of vascular damage. In addition, future perspectives of non-invasive optical imaging for evaluating vascular damage of V-PDT will be discussed.

Paper Details

Date Published: 20 February 2017
PDF: 4 pages
Proc. SPIE 10065, Biophotonics and Immune Responses XII, 1006504 (20 February 2017); doi: 10.1117/12.2253802
Show Author Affiliations
Buhong Li, Fujian Normal Univ. (China)
Ying Gu, Chinese PLA General Hospital (China)
Brian C. Wilson, Univ. of Toronto (Canada)
Univ. Health Network (Canada)


Published in SPIE Proceedings Vol. 10065:
Biophotonics and Immune Responses XII
Wei R. Chen, Editor(s)

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