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Proceedings Paper

Design optimization for accurate flow simulations in 3D printed vascular phantoms derived from computed tomography angiography
Author(s): Kelsey Sommer; Rick L. Izzo; Lauren Shepard; Alexander R. Podgorsak; Stephen Rudin; Adnan H. Siddiqui; Michael F. Wilson; Erin Angel; Zaid Said; Michael Springer; Ciprian N. Ionita
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Paper Abstract

3D printing has been used to create complex arterial phantoms to advance device testing and physiological condition evaluation. Stereolithographic (STL) files of patient-specific cardiovascular anatomy are acquired to build cardiac vasculature through advanced mesh-manipulation techniques. Management of distal branches in the arterial tree is important to make such phantoms practicable. We investigated methods to manage the distal arterial flow resistance and pressure thus creating physiologically and geometrically accurate phantoms that can be used for simulations of image-guided interventional procedures with new devices. Patient specific CT data were imported into a Vital Imaging workstation, segmented, and exported as STL files. Using a mesh-manipulation program (Meshmixer) we created flow models of the coronary tree. Distal arteries were connected to a compliance chamber. The phantom was then printed using a Stratasys Connex3 multimaterial printer: the vessel in TangoPlus and the fluid flow simulation chamber in Vero. The model was connected to a programmable pump and pressure sensors measured flow characteristics through the phantoms. Physiological flow simulations for patient-specific vasculature were done for six cardiac models (three different vasculatures comparing two new designs). For the coronary phantom we obtained physiologically relevant waves which oscillated between 80 and 120 mmHg and a flow rate of ~125 ml/min, within the literature reported values. The pressure wave was similar with those acquired in human patients. Thus we demonstrated that 3D printed phantoms can be used not only to reproduce the correct patient anatomy for device testing in image-guided interventions, but also for physiological simulations. This has great potential to advance treatment assessment and diagnosis.

Paper Details

Date Published: 13 March 2017
PDF: 12 pages
Proc. SPIE 10138, Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications, 101380R (13 March 2017); doi: 10.1117/12.2253711
Show Author Affiliations
Kelsey Sommer, Univ. at Buffalo (United States)
Toshiba Stroke and Vascular Research Ctr. (United States)
Rick L. Izzo, Univ. at Buffalo (United States)
Toshiba Stroke and Vascular Research Ctr. (United States)
The Jacobs Institute (United States)
Lauren Shepard, Univ. at Buffalo (United States)
Toshiba Stroke and Vascular Research Ctr. (United States)
Alexander R. Podgorsak, Univ. at Buffalo (United States)
Toshiba Stroke and Vascular Research Ctr. (United States)
Stephen Rudin, Univ. at Buffalo (United States)
Toshiba Stroke and Vascular Research Ctr. (United States)
Univ. at Buffalo Jacobs School of Medicine (United States)
Adnan H. Siddiqui, Toshiba Stroke and Vascular Research Ctr. (United States)
Univ. at Buffalo Jacobs School of Medicine (United States)
Michael F. Wilson, Univ. at Buffalo (United States)
Univ. at Buffalo Jacobs School of Medicine (United States)
Erin Angel, Toshiba America Medical Systems, Inc. (United States)
Zaid Said, Univ. at Buffalo Jacobs School of Medicine (United States)
Michael Springer, The Jacobs Institute (United States)
Ciprian N. Ionita, Univ. at Buffalo (United States)
Toshiba Stroke and Vascular Research Ctr. (United States)
Univ. at Buffalo Jacobs School of Medicine (United States)


Published in SPIE Proceedings Vol. 10138:
Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications
Tessa S. Cook; Jianguo Zhang, Editor(s)

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