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Proceedings Paper

Ultra-high throughput microfluidic optomechanical sensors (Conference Presentation)
Author(s): Kewen Han; Jeewon Suh; Alan Luo; Gaurav Bahl
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Paper Abstract

Optical resonators have enabled the label-free measurement of nanoparticles suspended in liquids, down to the resolution of individual viruses and large molecules, but are only able to quantify optical properties (refractive index, scattering, fluorescence). Additionally, these sensors are fundamentally limited by the random diffusion of particles to the sensing region, and thus only measure a tiny fraction of the analyte. We have developed a microfluidic optomechanical resonator capable of sensing freely flowing nanoparticles using the action of phonons that are coupled to light. The phonon mode of the system casts a nearly perfect net for measuring density, viscoelasticity, and compressibility of the particles that flow through, without being limited by random diffusion. Information on the mechanical properties of the particles is encoded in the light scattered from the thermal fluctuations of the phonon mode. We have also developed a new electro-opto-mechanical method for improving the sensing speed achievable with this technique. We demonstrate real-time particle transit measurements as fast as 400 microseconds, without any post-processing. We discuss how this novel technique can be used for ultra-high throughput analysis of mechanical properties of biological particles in liquids, enabling a new form of flow cytometry. (invited by Prof. Giuseppe Leo)

Paper Details

Date Published: 28 April 2017
PDF: 1 pages
Proc. SPIE 10111, Quantum Sensing and Nano Electronics and Photonics XIV, 101112A (28 April 2017); doi: 10.1117/12.2253534
Show Author Affiliations
Kewen Han, Univ. of Illinois at Urbana-Champaign (United States)
Jeewon Suh, Univ. of Illinois at Urbana-Champaign (United States)
Alan Luo, Univ. of Illinois at Urbana-Champaign (United States)
Gaurav Bahl, Univ. of Illinois at Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 10111:
Quantum Sensing and Nano Electronics and Photonics XIV
Manijeh Razeghi, Editor(s)

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