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Proceedings Paper

Rare-earth doped nanocomposites enable multiscale targeted short-wave infrared imaging of metastatic breast cancer
Author(s): Mark C. Pierce; Laura M. Higgins; Vidya Ganapathy; Harini Kantamneni; Richard E. Riman; Charles M. Roth; Prabhas V. Moghe
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Paper Abstract

We are investigating the ability of targeted rare earth (RE) doped nanocomposites to detect and track micrometastatic breast cancer lesions to distant sites in pre-clinical in vivo models. Functionalizing RE nanocomposites with AMD3100 promotes targeting to CXCR4, a recognized marker for highly metastatic disease. Mice were inoculated with SCP-28 (CXCR4 positive) and 4175 (CXCR4 negative) cell lines. Whole animal in vivo SWIR fluorescence imaging was performed after bioluminescence imaging confirmed tumor burden in the lungs. Line-scanning confocal fluorescence microscopy provided high-resolution imaging of RE nanocomposite uptake and native tissue autofluorescence in ex vivo lung specimens. Co-registered optical coherence tomography imaging allowed assessment of tissue microarchitecture. In conclusion, multiscale optical molecular imaging can be performed in pre-clinical models of metastatic breast cancer, using targeted RE-doped nanocomposites.

Paper Details

Date Published: 8 February 2017
PDF: 7 pages
Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 100430Z (8 February 2017); doi: 10.1117/12.2253511
Show Author Affiliations
Mark C. Pierce, Rutgers, The State Univ. of New Jersey (United States)
Laura M. Higgins, Rutgers, The State Univ. of New Jersey (United States)
Vidya Ganapathy, Rutgers, The State Univ. of New Jersey (United States)
Harini Kantamneni, Rutgers, The State Univ. of New Jersey (United States)
Richard E. Riman, Rutgers, The State Univ. of New Jersey (United States)
Charles M. Roth, Rutgers, The State Univ. of New Jersey (United States)
Prabhas V. Moghe, Rutgers, The State Univ. of New Jersey (United States)


Published in SPIE Proceedings Vol. 10043:
Diagnosis and Treatment of Diseases in the Breast and Reproductive System
Melissa C. Skala; Paul J. Campagnola, Editor(s)

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