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Proceedings Paper

Investigation of burn effect on skin using simultaneous Raman-Brillouin spectroscopy, and fluorescence microspectroscopy
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Paper Abstract

Burns are thermal injuries that can completely damage or at least compromise the protective function of skin, and affect the ability of tissues to manage moisture. Burn-damaged tissues exhibit lower elasticity than healthy tissues, due to significantly reduced water concentrations and plasma retention. Current methods for determining burn intensity are limited to visual inspection, and potential hospital x-ray examination. We present a unique confocal microscope capable of measuring Raman and Brillouin spectra simultaneously, with concurrent fluorescence investigation from a single spatial location, and demonstrate application by investigating and characterizing the properties of burn-afflicted tissue on chicken skin model. Raman and Brillouin scattering offer complementary information about a material's chemical and mechanical structure, while fluorescence can serve as a useful diagnostic indicator and imaging tool. The developed instrument has the potential for very diverse analytical applications in basic biomedical science and biomedical diagnostics and imaging.

Paper Details

Date Published: 21 March 2017
PDF: 6 pages
Proc. SPIE 10057, Multimodal Biomedical Imaging XII, 1005705 (21 March 2017); doi: 10.1117/12.2253474
Show Author Affiliations
Zachary Coker, Texas A&M Univ. (United States)
Air Force Research Lab. (United States)
Zhaokai Meng, Texas A&M Univ. (United States)
Maria Troyanova-Wood, Texas A&M Univ. (United States)
Andrew Traverso, Texas A&M Univ. (United States)
Charles Ballmann, Texas A&M Univ. (United States)
Georgi Petrov, Texas A&M Univ. (United States)
Bennett L. Ibey, Air Force Research Lab. (United States)
Vladislav Yakovlev, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 10057:
Multimodal Biomedical Imaging XII
Fred S. Azar; Xavier Intes, Editor(s)

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