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Proceedings Paper

Simulating tissue fiberation and polarization properties in solid phantoms (Conference Presentation)
Author(s): Haili Wang; Shu Wei Shen; Yingjie Qu; Mingzhai Z. Sun; Erbao Dong; Peng Fei Shao; Ronald X. Xu
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Paper Abstract

Polarization of biological tissue reflects birefringent characteristics of tissue components such as collagenous and elastic fibers. Polarimetry imaging techniques have been widely explored for disease diagnosis and therapeutic guidance. However, no traceable standard is available for calibration and validation of the polarimetry devices, partially due to the lack of reliable and stable tissue-simulating phantoms that simulate tissue birefringence properties. We propose a new method to fabricate tissue simulating phantoms that simulate tissue scattering and polarization characteristics. The substrate of the phantoms are made of polydimethylsiloxane (PDMS). The PDMS material is mixed with sucrose to simulate optical rotation characteristics of chiral molecules in tissue. Titanum dioxide (TiO2 ) particles are used to simulate organelle scattering properties of tissue. An electrostatic spinning method produces thin filaments with designated orientation and polarization characteristics to simulate collagen and elastic fiber orientation in biological tissue.By adjusting the concentration of the scattering particles and the arrangements of the fibers, the produced phantoms present different polarization characteristics. The proposed tissue-simulating phantoms can be potentially used to validate and calibrate the polarimetry medical devices.

Paper Details

Date Published: 20 April 2017
PDF: 1 pages
Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560F (20 April 2017); doi: 10.1117/12.2253452
Show Author Affiliations
Haili Wang, Univ. of Science and Technology of China (China)
Shu Wei Shen, Univ. of Science and Technology of China (China)
Yingjie Qu, Univ. of Science and Technology of China (China)
Mingzhai Z. Sun, Univ. of Science and Technology of China (China)
Erbao Dong, Univ. of Science and Technology of China (China)
Peng Fei Shao, Univ. of Science and Technology of China (China)
Ronald X. Xu, The Ohio State Univ. (United States)

Published in SPIE Proceedings Vol. 10056:
Design and Quality for Biomedical Technologies X
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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