Share Email Print
cover

Proceedings Paper

Physiological basis for noninvasive skin cancer diagnosis using diffuse reflectance spectroscopy
Author(s): Yao Zhang; Mia K. Markey; James W. Tunnell
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Diffuse reflectance spectroscopy offers a noninvasive, fast, and low-cost alternative to visual screening and biopsy for skin cancer diagnosis. We have previously acquired reflectance spectra from 137 lesions in 76 patients and determined the capability of spectral diagnosis using principal component analysis (PCA). However, it is not well elucidated why spectral analysis enables tissue classification. To provide the physiological basis, we used the Monte Carlo look-up table (MCLUT) model to extract physiological parameters from those clinical data. The MCLUT model results in the following physiological parameters: oxygen saturation, hemoglobin concentration, melanin concentration, vessel radius, and scattering parameters. Physiological parameters show that cancerous skin tissue has lower scattering and larger vessel radii, compared to normal tissue. These results demonstrate the potential of diffuse reflectance spectroscopy for detection of early precancerous changes in tissue. In the future, a diagnostic algorithm that combines these physiological parameters could be enable non-invasive diagnosis of skin cancer.

Paper Details

Date Published: 6 February 2017
PDF: 8 pages
Proc. SPIE 10037, Photonics in Dermatology and Plastic Surgery, 1003707 (6 February 2017); doi: 10.1117/12.2253332
Show Author Affiliations
Yao Zhang, The Univ. of Texas at Austin (United States)
Mia K. Markey, The Univ. of Texas at Austin (United States)
Univ. of Texas MD Anderson Cancer Ctr. (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 10037:
Photonics in Dermatology and Plastic Surgery
Bernard Choi; Haishan Zeng; Nikiforos Kollias, Editor(s)

© SPIE. Terms of Use
Back to Top