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Proceedings Paper

Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations
Author(s): Ted A. Laurence; Sonny Ly; Erika Fong; Maxim Shusteff; Amanda Randles; John Gounley; Erik Draeger
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Paper Abstract

The utility and accuracy of computational modeling often requires direct validation against experimental measurements. The work presented here is motivated by taking a combined experimental and computational approach to determine the ability of large-scale computational fluid dynamics (CFD) simulations to understand and predict the dynamics of circulating tumor cells in clinically relevant environments. We use stroboscopic light sheet fluorescence imaging to track the paths and measure the velocities of fluorescent microspheres throughout a human aorta model. Performed over complex physiologicallyrealistic 3D geometries, large data sets are acquired with microscopic resolution over macroscopic distances.

Paper Details

Date Published: 22 February 2017
PDF: 10 pages
Proc. SPIE 10076, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II, 100761E (22 February 2017); doi: 10.1117/12.2253319
Show Author Affiliations
Ted A. Laurence, Lawrence Livermore National Lab. (United States)
Sonny Ly, Lawrence Livermore National Lab. (United States)
Erika Fong, Lawrence Livermore National Lab. (United States)
Maxim Shusteff, Lawrence Livermore National Lab. (United States)
Amanda Randles, Duke Univ. (United States)
John Gounley, Duke Univ. (United States)
Erik Draeger, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 10076:
High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II
Kevin K. Tsia; Keisuke Goda, Editor(s)

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