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Proceedings Paper

Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images
Author(s): Li Qi; Jiang Zhu; Aneeka M. Hancock; Cuixia Dai; Xuping Zhang; Ron D. Frostig; Zhongping Chen
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Paper Abstract

Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it not only relates to the properties of the laser and the scattering particles, but also relates to the geometry of both directions of the laser beam and the flow. In this paper, focusing on the analysis of cerebral hemodynamics, we presents a method to quantify the total absolute blood flow velocity in middle cerebral artery (MCA) based on volumetric vessel reconstruction from pure DOCT images. A modified region growing segmentation method is first used to localize the MCA on successive DOCT B-scan images. Vessel skeletonization, followed by an averaging gradient angle calculation method, is then carried out to obtain Doppler angles along the entire MCA. Once the Doppler angles are determined, the absolute blood flow velocity of each position on the MCA is easily found. Given a seed point position on the MCA, our approach could achieve automatic quantification of the fully distributed absolute BFV. Based on experiments conducted using a swept-source optical coherence tomography system, our approach could achieve automatic quantification of the fully distributed absolute BFV across different vessel branches in the rodent brain.

Paper Details

Date Published: 17 February 2017
PDF: 4 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005331 (17 February 2017); doi: 10.1117/12.2253309
Show Author Affiliations
Li Qi, Beckman Laser Institute (United States)
Nanjing Univ. (China)
Southern Medical Univ. (China)
Jiang Zhu, Beckman Laser Institute (United States)
Aneeka M. Hancock, Univ. of California, Irvine (United States)
Cuixia Dai, Beckman Laser Institute (United States)
Xuping Zhang, Nanjing Univ. (China)
Ron D. Frostig, Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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