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Proceedings Paper

A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT
Author(s): Timothy C. Zhu; Michele M. Kim; Yi-Hong Ong; Rozhin Penjweini; Andreea Dimofte; Jarod C. Finlay; Carmen Rodriguez; Keith A. Cengel
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Paper Abstract

Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. A dualcorrection algorithm is used to improve the agreement between calculations and in-situ measurements. A comprehensive analysis of the distribution of light fluence during PDT is presented in both phantom conditions and in clinical cases.

Paper Details

Date Published: 21 February 2017
PDF: 7 pages
Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 1004709 (21 February 2017); doi: 10.1117/12.2253027
Show Author Affiliations
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Yi-Hong Ong, The Univ. of Pennsylvania Health System (United States)
Rozhin Penjweini, The Univ. of Pennsylvania Health System (United States)
Andreea Dimofte, The Univ. of Pennsylvania Health System (United States)
Jarod C. Finlay, The Univ. of Pennsylvania Health System (United States)
Carmen Rodriguez, The Univ. of Pennsylvania Health System (United States)
Keith A. Cengel, The Univ. of Pennsylvania Health System (United States)


Published in SPIE Proceedings Vol. 10047:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
David H. Kessel; Tayyaba Hasan, Editor(s)

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