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Proceedings Paper

Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip
Author(s): Fusheng Zhao; Suyan Qiu; Jingting Li; Wei-Chuan Shih
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Paper Abstract

Nanoplasmonic sensor has become a recent research focus due to its significant signal enhancement and robust signal transduction measured by various techniques. However, since the native gold surface does not have the capability to selectively bind target biomolecules, high molecular specificity has been a challenge. Nanoporous gold nanoparticle (NPG-NP) array chip showcases large specific surface area and high-density plasmonic field enhancement known as “hot-spots”. In this paper, we discuss strategies to enhance molecular specificity by functionalizing NPG-NP with unique bio-recognition elements towards both high sensitivity and specificity. A few examples will be given using existing and novel bio-recognition elements.

Paper Details

Date Published: 17 February 2017
PDF: 5 pages
Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 1008006 (17 February 2017); doi: 10.1117/12.2253011
Show Author Affiliations
Fusheng Zhao, Univ. of Houston (United States)
Suyan Qiu, Univ. of Houston (United States)
Jiangxi Academy of Agricultural Sciences (China)
Jingting Li, Univ. of Houston (United States)
Wei-Chuan Shih, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 10080:
Plasmonics in Biology and Medicine XIV
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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