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Proceedings Paper

Characteristic performance investigation of a photon counting detector for x-ray fluorescence imaging applications
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Paper Abstract

The characteristic performance of a photon counting detector for X-ray fluorescence (XRF) imaging of gold nanoparticles (GNPs) is investigated. The investigations are first performed in three aspects: X-ray photon energy (keV) to pulse height (mV) conversion, noise floor determination, and linear detection ranges. Then, theoretical models are applied to evaluate the detection efficiency of X-ray photons with respect to an increased incident photon rate. Last, through exciting 100% pure GNPs by a conventional X-ray tube operated at a voltage of 110kVp, we acquire XRF spectrum in the threshold mode, based on which multi-energy thresholds are selected for XRF imaging of GNPs with low concentrations. Preliminary XRF imaging results of GNPs obtained in the imaging mode are presented and analyzed. This investigation study is essential to the development of fast and accurate XRF imaging of GNPs as well as other high atomic (Z) imaging contrast agents absorbed in cancerous cells.

Paper Details

Date Published: 20 February 2017
PDF: 8 pages
Proc. SPIE 10065, Biophotonics and Immune Responses XII, 100650L (20 February 2017); doi: 10.1117/12.2253008
Show Author Affiliations
Liqiang Ren, The Univ. of Oklahoma (United States)
Univ. of Central Oklahoma (United States)
Muhammad U. Ghani, The Univ. of Oklahoma (United States)
Di Wu, The Univ. of Oklahoma (United States)
Yuhua Li, The Univ. of Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)
Ge Wang, Rensselaer Polytechnic Institute (United States)
Bin Zheng, The Univ. of Oklahoma (United States)
Hong Liu, The Univ. of Oklahoma (United States)


Published in SPIE Proceedings Vol. 10065:
Biophotonics and Immune Responses XII
Wei R. Chen, Editor(s)

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