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Proceedings Paper

Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves
Author(s): Shaozhen Song; Soon Joon Yoon; Łukasz Ambroziński; Ivan Pelivanov; David Li; Liang Gao; Tueng T. Shen; Matthew O'Donnell; Ruikang K. Wang
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Paper Abstract

Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at ~1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes per second), and total imaging time for a 6 x 6 x 3 mm volume is only 0.32 s. With a displacement sensitivity of ~10 nanometers, the proposed 4D imaging technique provides sufficient temporal and spatial resolution for real-time optical coherence elastography (OCE). Combined with a new air-coupled, high-frequency focused ultrasound stimulator requiring no contact or coupling media, this near real-time system can provide quantitative information on localized viscoelastic properties. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine cornea under various intra-ocular pressures. In addition, elasticity anisotropy in the cornea is observed. Images of the mechanical wave group velocity, which correlates with tissue elasticity, show velocities ranging from 4-20 m/s depending on pressure and propagation direction. These initial results strong suggest that 4D imaging for real-time OCE may enable high-resolution quantitative mapping of tissue biomechanical properties in clinical applications.

Paper Details

Date Published: 17 February 2017
PDF: 5 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100531Y (17 February 2017); doi: 10.1117/12.2252980
Show Author Affiliations
Shaozhen Song, Univ. of Washington (United States)
Soon Joon Yoon, Univ. of Washington (United States)
Łukasz Ambroziński, Univ. of Washington (United States)
AGH Univ. of Science and Technology (Poland)
Ivan Pelivanov, Univ. of Washington (United States)
Moscow State Univ. (Russian Federation)
David Li, Univ. of Washington (United States)
Liang Gao, Univ. of Washington (United States)
Tueng T. Shen, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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