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Proceedings Paper

Optical projection tomography via phase retrieval algorithms for hidden three dimensional imaging
Author(s): Daniele Ancora; Diego Di Battista; Georgia Giasafaki; Stylianos Psycharakis; Evangelos Liapis; Athanasios Zacharopoulos; Giannis Zacharakis
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Paper Abstract

Optical tomography in biomedical imaging is a highly dynamic field in which non-invasive optical and computational techniques are combined to obtain a three dimensional representation of the specimen we are interested to image. Although at optical wavelengths scattering is the main obstacle to reach diffraction limited resolution, recently several studies have shown the possibility to image even objects fully hidden behind a turbid layer exploiting the information contained in the speckle autocorrelation via an iterative phase retrieval algorithm. In this work we explore the possibility of blind three dimensional reconstruction approach based on the Optical Projection Tomography principles, a widely used tool to image almost transparent model organism such as C. Elegans and D. Rerio. By using autocorrelation information rather than projections at each angle we prove, both numerically and experimentally, the possibility to perform exact three dimensional reconstructions via a specifically designed phase retrieval algorithm, extending the capability of the projection-based tomographic methods to image behind scattering curtains. The reconstruction scheme we propose is simple to implement, does not require post-processing data alignment and moreover can be trivially implemented in parallel to fully exploit the computing power offered by modern GPUs, further reducing the need for costly computational resources.

Paper Details

Date Published: 21 February 2017
PDF: 7 pages
Proc. SPIE 10074, Quantitative Phase Imaging III, 100741E (21 February 2017); doi: 10.1117/12.2252894
Show Author Affiliations
Daniele Ancora, Foundation for Research and Technology-Hellas (Greece)
Univ. of Crete (Greece)
Diego Di Battista, Foundation for Research and Technology-Hellas (Greece)
Univ. of Crete (Greece)
Georgia Giasafaki, Univ. of Crete (Greece)
Stylianos Psycharakis, Foundation for Research and Technology-Hellas (Greece)
Evangelos Liapis, Foundation for Research and Technology-Hellas (Greece)
Athanasios Zacharopoulos, Foundation for Research and Technology-Hellas (Greece)
Giannis Zacharakis, Foundation for Research and Technology-Hellas (Greece)

Published in SPIE Proceedings Vol. 10074:
Quantitative Phase Imaging III
Gabriel Popescu; YongKeun Park, Editor(s)

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