Share Email Print

Proceedings Paper

Analyte detection in complex samples using a biomimetic, non-spectroscopic sensing method
Author(s): Kevin J. Major; Menelaos K. Poutous; Ishwar D. Aggarwal; Jasbinder S. Sanghera; Kenneth J. Ewing
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Optical sensing techniques for organic and biological molecules traditionally require the collection of complete, well-defined, vibrational spectra of a sample. The vibrational absorption bands of the spectra are identified, and statistical methods are then utilized to determine the moieties and concentration of target analytes present in a given sample. In this work, we present a new, non-spectroscopic alternative technique to molecular vibrational sensing. This biomimetic method, based on human color vision, uses only three broad, overlapping infrared (IR) optical filters to discriminate between chemicals with similar vibrational absorption bands. Unique detection vectors are defined by the interaction of a given chemical’s absorption bands with the three filter channels. Identification of the analytes present in a sample are then determined based on these detection vectors. We present multiple studies that demonstrate the ability of this approach to clearly discriminate between molecules with similar infrared vibrational absorption bands. We show that this method has the ability to precisely identify specific analytes in the presence of potential interferents with similar infrared absorption bands in the same sample. An optical filter based sensor that operates in the mid-IR using low power components, requiring no spectral scanning has been developed using this technique, and results using this sensor are shown. This method has the potential to lead the development of small, rugged optical sensors for non-invasive diagnostics and sensing of biological fluids.

Paper Details

Date Published: 17 February 2017
PDF: 7 pages
Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 100720Z (17 February 2017); doi: 10.1117/12.2252890
Show Author Affiliations
Kevin J. Major, Sotera Defense Solutions, Inc. (United States)
Menelaos K. Poutous, The Univ. of North Carolina at Charlotte (United States)
Ishwar D. Aggarwal, The Univ. of North Carolina at Charlotte (United States)
Sotera Defense Solutions, Inc. (United States)
Jasbinder S. Sanghera, U.S. Naval Research Lab. (United States)
Kenneth J. Ewing, U.S. Naval Research Lab. (United States)

Published in SPIE Proceedings Vol. 10072:
Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

© SPIE. Terms of Use
Back to Top