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Proceedings Paper

Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography
Author(s): Lu Ding; Xosé Luís Deán-Ben; Neal C. Burton; Robert W. Sobol; Vasilis Ntziachristos; Daniel Razansky
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Paper Abstract

Due to modeling and experimental imperfections, multispectral optoacoustic tomography images are often afflicted with negative values, which are further amplified when propagating into the spectrally unmixed images of chromophore concentrations. Since negative values have no physical meaning, accuracy can potentially be improved by imposing non-negativity constraints on the initial reconstructions and the unmixing steps. Herein, we compare several non-negative constrained approaches with reconstruction and spectral unmixing performed separately or combined in a single inverse step. The quantitative performance and sensitivity of the different approaches in detecting small amounts of spectrally-distinct chromophores are studied in tissue-mimicking phantoms and mouse experiments.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100641B (3 March 2017); doi: 10.1117/12.2252807
Show Author Affiliations
Lu Ding, Technical Univ. of Munich (Germany)
Helmholtz Zentrum München GmbH (Germany)
Xosé Luís Deán-Ben, Technical Univ. of Munich (Germany)
Helmholtz Zentrum München GmbH (Germany)
Neal C. Burton, iThera Medical GmbH (Germany)
Robert W. Sobol, Univ. of Pittsburgh School of Medicine (United States)
Vasilis Ntziachristos, Technical Univ. of Munich (Germany)
Helmholtz Zentrum München GmbH (Germany)
Daniel Razansky, Technical Univ. of Munich (Germany)
Helmholtz Zentrum München GmbH (Germany)


Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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