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Proceedings Paper

Application of kernel method in fluorescence molecular tomography
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Paper Abstract

Reconstruction of fluorescence molecular tomography (FMT) is an ill-posed inverse problem. Anatomical guidance in the FMT reconstruction can improve FMT reconstruction efficiently. We have developed a kernel method to introduce the anatomical guidance into FMT robustly and easily. The kernel method is from machine learning for pattern analysis and is an efficient way to represent anatomical features. For the finite element method based FMT reconstruction, we calculate a kernel function for each finite element node from an anatomical image, such as a micro-CT image. Then the fluorophore concentration at each node is represented by a kernel coefficient vector and the corresponding kernel function. In the FMT forward model, we have a new system matrix by multiplying the sensitivity matrix with the kernel matrix. Thus, the kernel coefficient vector is the unknown to be reconstructed following a standard iterative reconstruction process. We convert the FMT reconstruction problem into the kernel coefficient reconstruction problem. The desired fluorophore concentration at each node can be calculated accordingly. Numerical simulation studies have demonstrated that the proposed kernel-based algorithm can improve the spatial resolution of the reconstructed FMT images. In the proposed kernel method, the anatomical guidance can be obtained directly from the anatomical image and is included in the forward modeling. One of the advantages is that we do not need to segment the anatomical image for the targets and background.

Paper Details

Date Published: 15 February 2017
PDF: 8 pages
Proc. SPIE 10057, Multimodal Biomedical Imaging XII, 100570P (15 February 2017); doi: 10.1117/12.2252782
Show Author Affiliations
Yue Zhao, Univ. of California, Merced (United States)
Reheman Baikejiang, Univ. of California, Merced (United States)
Changqing Li, Univ. of California, Merced (United States)


Published in SPIE Proceedings Vol. 10057:
Multimodal Biomedical Imaging XII
Fred S. Azar; Xavier Intes, Editor(s)

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