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Proceedings Paper

Investigation of retinal microstructure in healthy eyes and dry age-related macular degeneration using a combined AO-OCT-SLO system
Author(s): Elaine M. Wells-Gray; Stacey S. Choi; Matthew Ohr; Colleen M. Cebulla; Nathan Doble
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Paper Abstract

Combined adaptive optics (AO) optical coherence tomography (OCT) scanning laser ophthalmoscopy (SLO) imaging allows simultaneous en face and cross sectional views of the retina. We describe improvements to our AO-OCT-SLO system and highlight its resolution capability and clinical utility by presenting results from 3 control and 4 dry agerelated macular degeneration (AMD) subjects. From a group of subjects with healthy eyes, OCT A-scans were grouped as originating from cones or rods and were averaged. The resulting reflectance profiles were then used to identify the location of cone and rod segments. Results for rods and cones were compared, with the focus on inner segment (IS) and outer segment (OS) structures and where these cells embed into the retinal pigment epithelium (RPE). In the AMD patients, cone IS and OS lengths were measured over and around drusen for two retinal regions (fovea–2° and 2°–4°), and those results were correlated to drusen height. For the fovea–2° region, the drusen height that caused statistically significant shortening of cone ISL and OSL compared to the unaffected adjacent area were 40 μm and 50 μm respectively (p = 0.009, and p < 0.001, respectively). For the 2°–4° region, the equivalent drusen heights that caused significant shortening of segment length were 60 μm for IS (p = 0.017) and 80 μm for OS (p < 0.001)

Paper Details

Date Published: 27 February 2017
PDF: 7 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004516 (27 February 2017); doi: 10.1117/12.2252720
Show Author Affiliations
Elaine M. Wells-Gray, The Ohio State Univ. (United States)
Stacey S. Choi, The Ohio State Univ. (United States)
Matthew Ohr, The Ohio State Univ. Havener Eye Institute (United States)
Colleen M. Cebulla, The Ohio State Univ. Havener Eye Institute (United States)
Nathan Doble, The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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