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Proceedings Paper

Imaging multi-scale dynamics in vivo with spiral volumetric optoacoustic tomography
Author(s): X. Luís Deán-Ben; Thomas F. Fehm; Steven J. Ford; Sven Gottschalk; Daniel Razansky
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Paper Abstract

Imaging dynamics in living organisms is essential for the understanding of biological complexity. While multiple imaging modalities are often required to cover both microscopic and macroscopic spatial scales, dynamic phenomena may also extend over different temporal scales, necessitating the use of different imaging technologies based on the trade-off between temporal resolution and effective field of view. Optoacoustic (photoacoustic) imaging has been shown to offer the exclusive capability to link multiple spatial scales ranging from organelles to entire organs of small animals. Yet, efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition and effective field of view. Herein, we introduce a spiral volumetric optoacoustic tomography (SVOT) technique that provides spectrally-enriched high-resolution optical absorption contrast across multiple spatio-temporal scales. We demonstrate that SVOT can be used to monitor various in vivo dynamics, from video-rate volumetric visualization of cardiac-associated motion in whole organs to high-resolution imaging of pharmacokinetics in larger regions. The multi-scale dynamic imaging capability thus emerges as a powerful and unique feature of the optoacoustic technology that adds to the multiple advantages of this technology for structural, functional and molecular imaging.

Paper Details

Date Published: 3 March 2017
PDF: 6 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642K (3 March 2017); doi: 10.1117/12.2252701
Show Author Affiliations
X. Luís Deán-Ben, Institute for Biological and Medical Imaging, Helmholtz Ctr. Munich (Germany)
Technical Univ. of Munich (Germany)
Thomas F. Fehm, Institute for Biological and Medical Imaging, Helmholtz Ctr. Munich (Germany)
School of Medicine, Technical Univ. of Munich (Germany)
Steven J. Ford, Institute for Biological and Medical Imaging, Helmholtz Ctr. Munich (Germany)
Technical Univ. of Munich (Germany)
Sven Gottschalk, Institute for Biological and Medical Imaging, Helmholtz Ctr. Munich (Germany)
Technical Univ. of Munich (Germany)
Daniel Razansky, Institute for Biological and Medical Imaging, Helmholtz Ctr. Munich (Germany)
School of Medicine, Technical Univ. of Munich (Germany)


Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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